Lab Animal Research

Pharmacological Model

Cardiovascular disorders:

  • MI/arrhythmias
  • Angina
  • Heart failure
  • Hypertension

Pulmonary disorders:

  • Asthma
  • COPD
  • IPF
  • Anaphylaxis/allergy

Diabetic and Metabolic Models:

  • Acute Model: Acute Dyslipidemia Model: corn oil / intralipid induced
  • Chronic Model: High-Fat diet-induced obesity mouse model
  • streptozotocin-induced Diabetes model

Obesity model:

  • Diet-induced obesity in rat, mice
  • Fructose-induced hypertriglyceridemia in rats
  • Hypercholesterolemia in rabbits

CNS:

  • Memory/cognition
  • Anxiety
  • Depression
  • Epilepsy
  • ADHD
  • Brain & Spine Injury Models
  • Parkinson’s Disease
  • Cognition / Motivation
  • Depression & Sexual Function
  • Schizophrenia & Mania
  • Alzheimer’s Disease-Scopolamine Treated Mice
  • Catalepsy
  • Neuroinflammation
  • Chemical-Induced Memory Impairment

Inflammation:

  • TNBS, oxazolone, DSS induced colitis

Arthritis:

  • Collagen Antibody Induced Arthritis
  • Pristane-Induced Arthritis in the Rat
  • Adjuvant-induced Arthritis
  • Carrageenan-induced chronic inflammatory arthritis
  • Osteoarthritis (OA) Animal Models

GI:

  • Ulcers
  • GI transit
  • GI emptying

Oncology:

In vivo – subcutaneous xenograft tumour models and chemical-induced carcinogenesis

  • Ovarian
  • Breast
  • Lung
  • Prostate
  • Brain
  • Gastric
  • Pancreatic
  • Colon
  • Epidermoid carcinoma
  • Melanoma
  • Leukaemia, etc.

Dermatology:

  • Dermal Efficacy & Models
  • Wound Healing Models
  • Burn Modeling
  • Dermatologic Inflammation
  • Delayed-Type Hypersensitivity (Dth) Studies

Ophthalmology:

  • Diabetic retinopathy (DR) model-Rat
  • Choroidal neovascularization (CNV) model-Mouse, Rat
  • Mouse dry eye disease model-Mouse
  • Retinal detachment model-Mouse
  • Glaucoma (ocular hypertension) animal model-Mouse, Rabbit, Rat

Drug Metabolism & Pharmacokinetics (DMPK):

  • CYP450 profiling
  • Caco-2 permeability
  • Solubility
  • Protein Binding Melanin Binding
  • Metabolite ID/Profiling
  • Matrix Stability
  • RBC Partitioning
  • Permeability and Efflux
  • Influx Transporters
  • hERG Inhibition
  • Cell Proliferation and Cytotoxicity
  • Pharmacokinetics / Toxicokinetics

Single bolus – Oral and intravenous route of administration:

  • Bioavailability
  • Metabolic Profiling
  • Specialized studies First pass / EHC / Portal / Excretion
  • Tissue distribution

Rodents & Non-Rodents Toxicology

General Toxicology:

  • Single Dose / Acute Toxicity
  • Repeated Dose /subacute Toxicity -14/28/90/180 day
  • Chronic Toxicity
  • Skin & Eye irritation
  • Skin sensitization
  • Inhalation Toxicity
  • Immunotoxicity

Genetic Toxicology:

  • Ames Test
  • Micronucleus-invivo /invitro
  • Chromosomal aberration-invitro
  • Mouse lymphoma assay
  • Comet Assay

Reproduction & Developmental Toxicity

Animal species: mice, rats, guinea pigs, hamsters, and rabbits.

Alternative to animal models

  • Skin corrosion – in vitro model
  • Ocular irritation – in vitro model
  • Oral irritation – in vitro model