Lab Animal Research
Pharmacological Model
Cardiovascular disorders:
- MI/arrhythmias
- Angina
- Heart failure
- Hypertension
Pulmonary disorders:
- Asthma
- COPD
- IPF
- Anaphylaxis/allergy
Diabetic and Metabolic Models:
- Acute Model: Acute Dyslipidemia Model: corn oil / intralipid induced
- Chronic Model: High-Fat diet-induced obesity mouse model
- streptozotocin-induced Diabetes model
Obesity model:
- Diet-induced obesity in rat, mice
- Fructose-induced hypertriglyceridemia in rats
- Hypercholesterolemia in rabbits
CNS:
- Memory/cognition
- Anxiety
- Depression
- Epilepsy
- ADHD
- Brain & Spine Injury Models
- Parkinson’s Disease
- Cognition / Motivation
- Depression & Sexual Function
- Schizophrenia & Mania
- Alzheimer’s Disease-Scopolamine Treated Mice
- Catalepsy
- Neuroinflammation
- Chemical-Induced Memory Impairment
Inflammation:
- TNBS, oxazolone, DSS induced colitis
Arthritis:
- Collagen Antibody Induced Arthritis
- Pristane-Induced Arthritis in the Rat
- Adjuvant-induced Arthritis
- Carrageenan-induced chronic inflammatory arthritis
- Osteoarthritis (OA) Animal Models
GI:
- Ulcers
- GI transit
- GI emptying
Oncology:
In vivo – subcutaneous xenograft tumour models and chemical-induced carcinogenesis
- Ovarian
- Breast
- Lung
- Prostate
- Brain
- Gastric
- Pancreatic
- Colon
- Epidermoid carcinoma
- Melanoma
- Leukaemia, etc.
Dermatology:
- Dermal Efficacy & Models
- Wound Healing Models
- Burn Modeling
- Dermatologic Inflammation
- Delayed-Type Hypersensitivity (Dth) Studies
Ophthalmology:
- Diabetic retinopathy (DR) model-Rat
- Choroidal neovascularization (CNV) model-Mouse, Rat
- Mouse dry eye disease model-Mouse
- Retinal detachment model-Mouse
- Glaucoma (ocular hypertension) animal model-Mouse, Rabbit, Rat
Drug Metabolism & Pharmacokinetics (DMPK):
- CYP450 profiling
- Caco-2 permeability
- Solubility
- Protein Binding Melanin Binding
- Metabolite ID/Profiling
- Matrix Stability
- RBC Partitioning
- Permeability and Efflux
- Influx Transporters
- hERG Inhibition
- Cell Proliferation and Cytotoxicity
- Pharmacokinetics / Toxicokinetics
Single bolus – Oral and intravenous route of administration:
- Bioavailability
- Metabolic Profiling
- Specialized studies First pass / EHC / Portal / Excretion
- Tissue distribution
Rodents & Non-Rodents Toxicology
General Toxicology:
- Single Dose / Acute Toxicity
- Repeated Dose /subacute Toxicity -14/28/90/180 day
- Chronic Toxicity
- Skin & Eye irritation
- Skin sensitization
- Inhalation Toxicity
- Immunotoxicity
Genetic Toxicology:
- Ames Test
- Micronucleus-invivo /invitro
- Chromosomal aberration-invitro
- Mouse lymphoma assay
- Comet Assay
Reproduction & Developmental Toxicity
Animal species: mice, rats, guinea pigs, hamsters, and rabbits.
Alternative to animal models
- Skin corrosion – in vitro model
- Ocular irritation – in vitro model
- Oral irritation – in vitro model